Nutrients, Free Full-Text
4.6 (759) · $ 8.50 · In stock
Stevioside, one of the natural sweeteners extracted from stevia leaves, and its derivatives are considered to have numerous beneficial pharmacological properties, including the inhibition of activated coagulation factor X (FXa). FXa-PAR signaling is a possible therapeutic target to enhance impaired metabolism and insulin resistance in obesity. Thus, the goal of the investigation was a QSAR analysis using multivariate adaptive regression splines (MARSplines) applied to a data set of 20 isosteviol derivatives bearing thiourea fragments with possible FXa inhibitory action. The best MARS submodel described a strong correlation between FXa inhibitory activity and molecular descriptors, such as: B01[C-Cl], E2m, L3v, Mor06i, RDF070i and HATS7s. Five out of six descriptors included in the model are geometrical descriptors quantifying three-dimensional aspects of molecular structure, which indicates that the molecular three-dimensional conformation is of high significance for the MARSplines modeling procedure and obviously for FXa inhibitory activity. High model performance was confirmed through an extensive validation protocol. The results of the study not only confirmed the enhancement in pharmacological activity by the presence of chlorine in a phenyl ring, but also, and primarily, may provide the basis for searching for new active isosteviol analogues, which may serve as drugs or health-beneficial food additives in patients suffering from obesity and comorbidities.
Nutrients, Free Full-Text, press f to respect significado
Fiber, genes and the gut microbiome: Study reveals possible
Nutrients, Free Full-Text, press f to respect significado
Mega-nutrients for your nerves : Newbold, H. L. (Herbert Leon
Full Throttle Original Citrus Energy Drink, 16 fl oz - The Fresh
Nutrients Free Full Text Rosmarinus Officinalis And Mentha Piperita 92192
Nutrition facts label Vectors & Illustrations for Free Download
The Best Whey Protein Powders in 2024, Tested by Men's Health
Nutrients Free Full-Text Potential Of Egg As Complementary
Boxplots of the major nutrients (g/100g) in all gluten-containing
Space Food for Thought: Challenges and Considerations for Food and
Nutrients, Free Full-Text, o que significa a fórmula y=c+i+g+(x-m)
Nutrients, Free Full-Text, kelly godoy coelho